The . Food and Drug Administration (FDA) notes that improper dosing is one of the biggest problems in giving acetaminophen (paracetamol) to children.  The effectiveness of acetaminophen alone as an antipyretic in children is uncertain, with some evidence showing it is no better than physical methods.  Therapies involving alternating doses of acetaminophen and ibuprofen have shown greater antipyretic effect than either drug alone.  One meta-analysis indicated that ibuprofen is more effective than acetaminophen in children at similar doses when both are given alone.