Biosynthesis of adrenocortical steroid hormones

The core macrocycle , prerapamycin (figure 2), is then modified (figure 3) by an additional five enzymes, which lead to the final product, rapamycin. First, the core macrocycle is modified by RapI, SAM-dependent O-methyltransferase (MTase), which O-methylates at C39. Next, a carbonyl is installed at C9 by RapJ, a cytochrome P-450 monooxygenases (P-450). Then, RapM, another MTase, O-methylates at C16. Finally, RapN, another P-450, installs a hydroxyl at C27 immediately followed by O-methylation by Rap Q, a distinct MTase, at C27 to yield rapamycin. [37]

1. Metabolism
     Global/overview    Carbohydrate    Energy    Lipid    Nucleotide    Amino acid    Other amino    Glycan
     Cofactor/vitamin    Terpenoid/PK    Other secondary metabolite    Xenobiotics    Chemical structure
2. Genetic Information Processing
3. Environmental Information Processing
4. Cellular Processes
5. Organismal Systems
6. Human Diseases
7. Drug Development

Polyketides are structurally a very diverse family of natural products with diverse biological activities and pharmacological properties. [3] They are broadly divided into three classes: type I polyketides (often macrolides produced by multimodular megasynthases ), type II polyketides (often aromatic molecules produced by the iterative action of dissociated enzymes ), and type III polyketides (often small aromatic molecules produced by fungal species). Polyketide antibiotics , antifungals , cytostatics , anticholesteremic , antiparasitics , coccidiostats , animal growth promoters and natural insecticides are in commercial use. [ citation needed ]

Biosynthesis of adrenocortical steroid hormones

biosynthesis of adrenocortical steroid hormones

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