Ecdysteroid wiki

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Ecdysteroids are probably the most abundant steroids in nature because they are produced not only by arthropods, but also by many plant species. They seem to display a wide array of pharmacological effects on vertebrates, many of which are beneficial. However, these claims require more thorough validation and clinical testing. Ecdysteroids are used by an increasing number of humans as anabolic compounds, and it may well be that in the near future they will also be used on domesticated animals. This is the reason why new methods of detection and quantification have been recently proposed (Tsitsimpikou, 2001; Le Bizec, 2002) and further developments in this area are required. Whether ecdysteroid use will become controlled (. for high-performance sportsmen or domestic animals [. race horses]) is still open.
Ecdysteroids have also been successfully developed as effective inducers for gene switch control systems, several of which are presently in use. Ecdysteroids and/or bisacylhydrazines fulfil many of the required criteria, but not all. There are still problems which need to be overcome (. the need for highly potent ligands for modified ecdysteroid receptors in transformed mammalian or plant cells). However, there is clearly great potential in this area. The future of ecdysteroid-regulated gene switches as an experimental tool is assured, but the prospects as in vivo systems is more debatable; the numerous pharmacological effects of ecdysteroids may preclude the development of their use in humans for gene therapy systems. This can only be resolved if more effort is invested into examining the biochemical fate and pharmacological consequences of ecdysteroids in mammals, especially humans.

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Ecdysteroid wiki

ecdysteroid wiki

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