H295r steroidogenesis

I suggested this to a few of my patients who I suspected were suffering from this specific scenario.  At first, I was unsure if a simple cup of rooibos tea would be strong enough to have any significant impact.  I was pleasantly surprised to find all them had noticeable results within a month.  Every single one of them reported feeling calmer.  Several of them reported an improvement in their sex drive.  One of them had her high blood pressure return to normal within three weeks.  All of them had significantly easier periods with fewer cramps and clots.  One of them had a normal period for the first time in years.  Previously, her periods were coming every three weeks and were accompanied by heavy bleeding.  She was chronically anemic and alway felt worse with progesterone. This same lady ended up needing to reduce her dose of thyroid medication, which had been the same for years.  I’m guessing this is partly because of the effects of cortisol on the thyroid through the adrenal-thyroid axis and maybe partly because progesterone boosts thyroid function.  My acne patients who had symptoms of this scenario all improved by at least 20% and two ladies improved by about 70% after one month.  Acne is multifaceted so it would be unlikely that rooibos tea would act as a magic pill but it definitely seems to help.   I was REALLY encouraged by these results.  The lady who had the high blood pressure had a relapse about two months after.  At first we couldn’t figure out why but then realized that she had bought some rooibos tea that contained licorice, which is known to elevate blood pressure.  When she stopped this her blood pressure returned back to normal within a week.  There are a couple unknowns here.  To reduce overall inflammation, I have all of my patients stop drinking coffee and alcohol and reduce their sugar intake to less than 7 grams per meal.  If someone is still consuming these, I’m not sure if some of these substances might override the beneficial effects of the rooibos and continue to drive the pathway in the wrong direction.  I would LOVE to hear your feedback.

Reproductive Toxicity:   PFOA is a known developmental toxicant 25 . PFOA exposure in utero leads to reduced weight gain during lactation, delayed sexual maturation and death in rodents 26 . In humans, PFOA exposure was associated with pregnancy-induced hypertension (high-blood pressure), and PFOS was associated with reduced birth-weight in full-term infants 27 . Higher levels of the chemical in cord blood were associated with both lower birth weight and smaller size, indicating an effect of PFOA on prenatal development 28 . In a novel study of PFOA exposures among pregnant women in an electronic waste recycling area in China, mothers living in the area had higher PFOA levels than mothers in other areas; and exposures were associated with delayed physical development and adverse birth outcomes. 29 

29 Honey bee larval toxicity tests complement OECD TGs 213 and 214 on young adult honey bees and should be seen as a lower tier screening test.
30 “Generally, waivers are considered when there is little or no significant human exposure by a given route of exposure or when it is technically not possible to perform a study for a certain endpoint, such as not requiring an acute oral toxicity study when the test chemical exists as a vapour or gas. Waivers are also possible taking into account animal welfare considerations, such as when the test chemical is corrosive.”
31 U-SENS™ is proposed to address the third key event of the skin sensitization AOP; recommended by EURL ECVAM as part of an IATA to support discrimination between sensitizers and non-sensitizers for hazard classification and labelling.
32 “IL-8 Luc assay is proposed to address the third key event (dendritic cell activation) of the skin sensitisation AOP by quantifying changes in the expression of cytokine associated with the process of activation of DC (. IL-8), in the human monocytic leukemia cell line THP-1-derived IL-8 reporter cell line, THP-G8, following exposure to sensitisers.”
33 EPAA-IIVS Video of 3T3 NRU Phototoxicity Assay.
34 EPAA-IIVS Video of BCOP Eye Irritation Assay.

H295r steroidogenesis

h295r steroidogenesis

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