The “ Cell Journal (Yakhteh) “, formerly published as “Yakhteh Medical Journal”, is a quarterly English publication of Royan Institute . This journal focuses on topics relevant to cellular and molecular scientific areas, besides other related fields. The Cell J has been certified by Ministry of Culture and Islamic Guidance in 1999 and was accredited as a scientific and research journal by HBI (Health and Biomedical Information) Journal Accreditation Commission in 2000 which is an open access journal.
A far more common cause of excess production of androgens in women is polycystic ovary syndrome (PCOS; also called Stein-Leventhal syndrome ). This syndrome is characterized by excess androgens and the presence of a menstrual disorder. Androgen excess often manifests as hirsutism, with or without increased serum concentrations of one or more androgens. Some women have increased serum androgen concentrations and no hirsutism. A variety of menstrual disorders have been associated with PCOS, including oligomenorrhea, amenorrhea, anovulation, and infertility . An ultrasound may reveal multiple ovarian cysts. Many women with this syndrome are obese . Another characteristic feature of PCOS is tissue resistance to the action of insulin . This is expected in obese women, but it is also present in nonobese women with the syndrome. Insulin resistance leads to an increase in insulin secretion (hyperinsulinemia), which is thought to stimulate ovarian androgen production. Hyperinsulinemia also decreases the production of sex hormone-binding globulin so that more of the testosterone in the serum is free and accessible to the tissues. In addition, the conversion of androgens to estrogens in adipose tissue is increased (particularly in obese women), which leads to a small sustained increase in the secretion of luteinizing hormone and to the suppression of ovulation .