A Phase 4 study (DAP-PEDS-07-03) was conducted to assess safety, efficacy, and pharmacokinetics of daptomycin in paediatric patients (1 to 17 years old, inclusive) with cSSTI caused by Gram-positive pathogens. Daptomycin pharmacokinetics in patients in this study are summarized in Table 2. Following administration of multiple doses, daptomycin exposure was similar across different age groups after dose adjustment based on body weight and age. Plasma exposures achieved with these doses were consistent with those achieved in the adult cSSTI study (following 4 mg/kg once daily in adults).
Our needles start with 10, 20,30 up to 100. In other words they go by 10’s and each hash mark between go by 2’s. Example: Between 10 and 20 there are 4 other marks. 10 12 14 16 18 20. Very difficult to see where or 15 would be! My son will be doing it and from what I read men do better on 200 so at least he can use them easier then me! Just thought I’d let you know there are other types out there. Thanks for your blog. It’s been very helpful. We are not newbies to hcg but we were mixing 30ml to 5000 and doing 50 unit shots.
The ‘Two-Pin’ technique increases sanitation for multiple dose vial users. They draw with the first pin, and then shoot/inject into the body with a new one. This procedure prevents any residual contaminants that may have remained on the drawing pin from being transferred into the body via the injection site. It also makes injection less painful since the drawing needle is necessarily dulled during passage through the rubber stopper atop the vial. A dulled needle increases injection pain because it doesn’t pierce the body as cleanly as an unused one. The protocol below is followed by AAS users who draw from multiple dose vials, but steps 4 - 8 are routinely disregarded by those users who draw from ampoules (also called ampules) and sachets.