Steroid hormones work according to a method called

Depending on the number and character of their functional groups, steroid molecules may show diverse reactivities. Moreover, the reactivity of a functional group varies according to its location within the molecule (for example, esters are formed readily by 3-OH groups but only with difficulty by the 11β-OH group). An important property of steroids is polarity —., their solubility in oxygen-containing solvents (., water and alcohols ) rather than hydrocarbon solvents (., hexane and benzene ). Hydroxyl, ketonic, or ionizable (capable of dissociating to form electrically charged particles) groups in a steroid molecule increase its polarity to an extent that is strongly influenced by the spatial arrangement of the atoms within the molecule.

Laws and Penalties:  Concerns over growing illegal AAS abuse by teenagers, and many of the just discussed long-term effects, led Congress in 1991 to place the whole AAS class of drugs into Schedule III of the Controlled Substances Act (CSA).  Under this legislation, AAS are defined as any drug or hormonal substance, chemically and pharmacologically related to T (other than estrogens, progestins, and corticosteroids) that promotes muscle growth.  The possession or sale of AAS without a valid prescription is illegal.  Since 1991, simple possession of illegally obtained AAS carry a maximum penalty of one year in prison and a minimum $1,000 fine if this is an individual’s first drug offense.  The maximum penalty for trafficking (selling or possessing enough to be suspected of selling) is five years in prison and a fine of $250,000 if this is the individual’s first felony drug offense.  If this is the second felony drug offense, the maximum period of imprisonment and the maximum fine both double.  While the above listed penalties are for federal offenses, individual states have also implemented fines and penalties for illegal use of AAS.  State executive offices have also recognized the seriousness of AAS abuse and other drugs of abuse in schools. For example, the State of Virginia enacted a law that will allow student drug testing as a legitimate school drug prevention program (48, 49).

Testosterone can be administered parenterally , but it has more irregular prolonged absorption time and greater activity in muscle in enanthate , undecanoate , or cypionate ester form. These derivatives are hydrolyzed to release free testosterone at the site of injection; absorption rate (and thus injection schedule) varies among different esters, but medical injections are normally done anywhere between semi-weekly to once every 12 weeks. A more frequent schedule may be desirable in order to maintain a more constant level of hormone in the system. [56] Injectable steroids are typically administered into the muscle, not into the vein, to avoid sudden changes in the amount of the drug in the bloodstream. In addition, because estered testosterone is dissolved in oil, intravenous injection has the potential to cause a dangerous embolism (clot) in the bloodstream.

In negative feedback regulation, the initial stimulus is reduced by the response it provokes. The response eliminates the initial stimulus and the pathway is halted. Negative feedback is demonstrated in the regulation of red blood cell production or erythropoiesis. The kidneys monitor oxygen levels in the blood. When oxygen levels are too low, the kidneys produce and release a hormone called erythropoietin (EPO). EPO stimulates red bone marrow to produce red blood cells. As blood oxygen levels return to normal, the kidneys slow the release of EPO resulting in decreased erythropoiesis.

Steroid hormones work according to a method called

steroid hormones work according to a method called

In negative feedback regulation, the initial stimulus is reduced by the response it provokes. The response eliminates the initial stimulus and the pathway is halted. Negative feedback is demonstrated in the regulation of red blood cell production or erythropoiesis. The kidneys monitor oxygen levels in the blood. When oxygen levels are too low, the kidneys produce and release a hormone called erythropoietin (EPO). EPO stimulates red bone marrow to produce red blood cells. As blood oxygen levels return to normal, the kidneys slow the release of EPO resulting in decreased erythropoiesis.

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