Steroid induced diabetes in children

In addition to the mentioned side effects several others have been reported. In both males and females acne are frequently reported, as well as hypertrophy of sebaceous glands, increased tallow excretion, hair loss, and alopecia. There is some evidence that anabolic steroid abuse may affect the immune system, leading to a decreased effectiveness of the defense system. Steroid use decreases the glucose tolerance, while there is an increase in insulin resistance. These changes mimic Type II diabetes. These changes seem to be reversible after abstention from the drugs.

At present, novel glucocorticoid receptor agonists are being developed that aim to display less metabolic adverse effects, with intact anti-inflammatory efficacy. These compounds are based on the more recent observation that the anti-inflammatory actions of glucocorticoids are achieved through different nuclear pathways than most of their (metabolic) side effects. Whereas the anti-inflammatory actions of glucocorticoids are mostly achieved by inhibition of genes (‘transrepression’), the side effects of glucocorticoids are mostly consequential to activation of genes (‘transactivation’). The novel compounds are called dissociated glucocorticoid receptor agonists and are designed to specifically induce transrepression. Currently, a great number of pharmaceutical companies are developing glucocorticoid compounds with a dissociated profile [14] . Although these agenta have so far shown promising results in preclinical studies, few data are currently available in humans.

Steroid induced diabetes in children

steroid induced diabetes in children

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