Dr. Bek collaborates with genetic research groups around the world and is credited with the discovery of a previously unknown genetic disease affecting Tenterfield terriers (Congenital Hypothyroidism with Goiter, or CHG). Working with Professor John C. Fyfe, ., ., Associate Professor of Microbiology and Molecular Genetics at Michigan State University over a period of two years she also played a role in the successful development of a buccal swab for DNA testing for carriers of the disease. The majority of breeding stock of Tenterfield Terriers in Australia has now been tested and carriers are being identified, making it possible for CHG to ultimately be eliminated from the breed.
There is variation in the literature with regard to dosage regimens. Prednisone mg/kg/day to 1 mg/kg/day PO is commonly reported, followed by gradual taper over 3 to 6 weeks. Use of IV methylprednisolone for a few days may precede oral corticosteroid use. NOTE: Following biopsy to confirm diagnosis, corticosteroids are usually instituted soon afterward as an adjunctive measure; removal of the suspected offending agent /cause is the primary treatment. While many case reports suggest a possible net benefit to the use of corticosteroids, some experts advocate for more prospective study of their value.