Prednisone can interact with a number of different drugs, including OTC and some herbal preparations. Let your doctor know about all the medications you take. The most common interactions are with NSAIDs , anti-infectives (such as ciprofloxacin , some HIV medicines ), immune suppressants , diuretics ("water” pills), and anticoagulants (blood thinners), but there are many more. If you are worried that some of your medicines may be interacting, talk with your doctor or pharmacist. Alternatively, you can use our drug interaction checker .